Successful Treatment of Aspergillus Sinusitis with Oral Voriconazole: A Case Report

Aspergillus sinusitis is an infection that can cause high mortality without appropriate treatment. The infection is not only found in immunocompromised patients, but also in immunocompetent patients. Management approaches to Aspergillus sinusitis include surgical debridement and intravenous or oral antifungal agents, including traditional intravenous amphotericin B. Here we describe a case of Aspergillus sinusitis with maxillary and orbital bony destruction. After surgical debridement, oral voriconazole was given to this patient due to the fact that he had poor renal function. After he had been administered with voriconazole 400 mg/day for 33 days, the infection was resolved completely. (J Intern Med Taiwan 2011; 22: 63-68)